Bouveault aldehyde synthesis(or Bouveault Reaction) 人名反应格式反应机理碳负离子醛合成

The reaction for synthesis of aldehydes by the treatment of N, N-disubstituted formamides (DMF) with either Grignard reagent or organic lithium reagent in an ether solvent (OR THF) is generally known as Bouveault aldehyde synthesis. 

The first step of the Bouveault aldehyde synthesis is the formation of the Grignard reagent or organic lithium reagent . Upon addition of a N,N-disubstituted formamide (such as DMF) a hemiaminal is formed, which can easily be hydrolyzed into the desired aldehyde .

首先卤代烃与镁反应生成相应的格氏试剂，然后加入 N,N-二取代甲酰胺（如二甲基甲酰胺），格氏试剂与之作用产生半胺醛（hemiaminal）中间体，该中间体经水解便很容易得到醛。

Example:

Cited:
http://www.sciencedirect.com/science/article/pii/S0040403900876157#
http://pubs.acs.org/doi/suppl/10.1021/ma500486u/suppl_file/ma500486u_si_001.pdf